ستاد توسعه زیست فناوری

In The Name Of Allah

Curriculum Vitae

Abbas S. Lotfi

I. PERSONAL INFORMATION :

II. EDUCATIONAL RECORDS :

III. FOREIGN LANGUAGES :

IV. POSITION HELD :

V. PRESENT POSITION :

III.IV. MEMBERSHIP OF SCIENTIFIC SOCIETIES : 

1. Iranian biochemistry society

2. Iranian biology society

3.  Iranian biotechnology association

4. Association of clinical biochemists ,UK

V. REFEREE FOR JOURNAL ARTICLES SUBMITTED TO :

1. Iranian Journal for Medical Sciences

2. Daneshvar

3. Modarres ,Journal for basic medical sciences

4. Hakim

5. Iranian Journal of Biotechnology

VI. RESEARCH INTERESTS :

1. Inborn error of metabolism (Alpha 1-antitrypsin deficiency), phenotyping , genotyping and family study

2. Alpha 1-Antitrypsin deficiency and related  diseases Conformational diseases: Serpins and Neuroserpin

3. Production of recombinant enzymes for enzyme therapy  

Thesis :

1. I Was responsible for submission of the following thesis: 

2. Lactate dehydrogenase changes in acute leukemia. hassan shahi, Tarbiat Modarres Univ. MSc. 1992.

3. Isolation, purification and characterization of Uricase from Candida Utilize. R. Bagherium, Tehran University, MSc. 1993.

4. Isolation, purification and characterization of Uri case from three plant sources for clinical perpses. B. G. Goodarzi, Tehran University, M.Sc. 1994.

5. Some biochemical aspects of asthma. H. Sanati, Rafsanjan University for Medical Sciences, M. D. 1991.

6. Investigation of phosphogluco isomerase and aldolase activities in mucosal tissue of esophageal cancer. S. Hassan neia, Tehran University for Medical Sciences, M. Sc. 1994.

7. Evaluation of Alpha 1- antitrypsin activity and its phenotyping in idiopathic neonatal liver diseases   S. Ghavami, Tarbiat Modarres University , M.Sc. 1995.

8. Alpha - 1- antitrypsin is enzymes in hepatitis and hepatitis causes. B. Milani. Tehran Modarres University M.Sc. 1995.

9. Alpha 1- atitrypsin deficiency and its phenotyping in emphysma .D. Hamidi, Tarbiat Modarres University M.Sc. 1996.

10. Investigation of Alpha 1- antitrypsin in sera of vascolitis patients with ANCA positive, R. Akhavan, Iran University for Medical  Sciences. Laboratory Sciences doctor, 1998.

11. Determination of lactate dehydrogenase and aldolase activities in severe physical training after administration of sucrose solution. Jafari A., Guilan University. M.Sc. 1997.

12. The clinical value of serum lactate dehydrogenase and its is enzymes in chronic leukemia patients, Sharifi M., Tarbiat Modarres University, M.Sc., 1999.

13. Production, purification of characterization of d- glucose oxides from Aspergillus. Niger, Hakhamaneshi S., Tarbiat Modares University, M.Sc. 2000.

14. Isolation and partial purification of alpha 1-antitrypsin from human plasma. Adibi B. Tarbiat Modares University, M.Sc. 2001.

15. Comparison of the virulence of candida albicance‏ isolates of evlutionof estrase a00tivity,M.Riazipoor,Ph.D. 2001

16. Evaluation of some urinary medium-chain  fatty acid metabolites in patient with MCAD and determination of suitable markers by G.C.,A.Mohsenifar,M.S.,2001

17. Expression of Neuroserpin in prokaryotic system and evaluation of structural and functional changes of Neuroserpin in oxidative stress, Mohsenifar A., Ph.D. Thesis

18. Assessment of yeast intron insertion on mRNA stability and expression of human alpha 1-antitrypsin cDNA in Saccharomyces Cerevisiae. Hasannia S., Ph.D. Thesis

19. Determination of gene frequency of A1AT-deficient alleles in related disease in Tehran. Goudarzi B.G., Ph.D. Thesis

 

VII. JOURNAL PAPERS [Author(s),  (Year),Title , Journal Name, Volume(Number) ,  Page(s)] :

1. Lotfi A. S. (1987) Vitamine C and its properties, J. Darou va Darman

2. Lotfi A. S. & Djavadi E. (1987) Clinical chemistry and medical Engineering, Proceeding of the congress, : 37- 41.

3. Lotfi A. S. & Farzami B. (1988) The effect of blood lead concentration on in vivo glucose 6- phosphate dehydrogenase activity, Enzyme, 43: 76- 77.

4. Lotfi A. S. & Farzami B. (1989) Determination of blood & urine lead level in nine aged children of various regions of Tehran and its correlation with Hb and G-6 - PHD activity, J. of School of Medicine, Tehran University of Medical Sciences, 6: 11- 16.

5. Lotfi. A. S. , Zaidi C. & Djalali M. (1992) Evaluation of N- acetyle - B - D- glucosaminidase (E. C. 3.2.2.26) is enzyme activity in esophageal cancer subjects, "Progress in clinical biochemistry" Elseivier Science Publisher: 731- 4.

6. Lotfi A. S. , Zaidi C, & Djalali M. (1993)Towards characterization of a proteic tumor marker in sera from esophageal cancer patients. proceeding of the" International symposium on protein structure function relationship": 171- 77.

7. Lotfi A. S. & Hamidi D. (1997) A study on α - 1 antitrypsin deficiency and its isoforms in emphisma. J. of Guilan Univ. for  Medical Sciences, (25- 26): 62- 67.

8. Lotfi A. S. & Zarei A. B. (1998) Investigation of diagnostic value of urinary NAG., β–   Galactosidase  and β - Glucosidase activities in chronic renal failure, Daneshvar, 5 (20): 39- 44.

9. Lotfi A. S., Malekzadeh R. & Milani B. (1999) The comparison of α 1- antitrypsin phenotypes in some HBSAg - positive patients with and without cirrhosis in Tehran. The J. of Kerman Univ. of Medical Sciences. Vol. 6. No. 1: 17-22 

10. Lotfi A. S., Sharifi M. R., Kaviani S. and  Jahani M. (2000) Lactate dehydrogenase isoenzymes ratio is a valuable tool for stage diagnosis monitoring therapy of chronic leukemia. Modarres J. of Medical Sciences. 2 (2): 2.

11. Lotfi A. S and Djalali M.(2000) Possible correlation between urinary muramidase and esophageal cancer. Cancer Letters, 158  : 113- 117.

12. Lotfi A. S., Hakhamanesh M. S. Yadegari M. H. and Mesbah S.A. (2001) Optimization of glucose oxidase production by Aspergillus Niger. Pajouhesh - va- Sazandegi, 14(2), :6-7

13. Lotfi A. S., Ghavami S., Malekzadeh R.(2002) Investigation of serum alpha 1- antitrypsin  isoforms in groups of patients with idiopathic liver disease . Kowsar Medical J. 7(1) :35-40.

14. Kabir-Salmani M, Shiokawa S, Akimoto Y, Sakai K, Nagamatsu S, Sakai K, Nakamura Y, Lotfi A.S wakami H. and Iwashita M. (2003) αVβ3 integrin signaling pathway is involved in insulin-like growth factor I-stimulated human extravillous trophoblast cell migration. Endocrinology , 144(4):1620-30.

15. Allameh, B.A. Mashkani, Lotfi A. S. (2003) Responses of brain cytosolic and microsomal glutathione S-transferase to theophylline in adult and suckling rats. Iranian Journal of Science & Technology

16.  Mahdavi Omran S., Lotfi A.S. , A. Khosravi, M. Salehnia, A. Zavvaran Hoseini, A. Kazemnejad (2003) Evaluation of the elastase activity of different aspergillus fumigatus isolated from human and animal cases.

17. S. Hasannia, F. Mir Blook, Lotfi A. S. , Mohsenifar A. , M. Mahmoodi , Serum HDL2-C evaluation in patients with coronary heart disease , J. of Rafsanjan University of Medical Sciences

18. Mohsenifar A., Lotfi A. S, Ranjbar B. , Allameh A. , Hasani L. , Etemadi Kia B. , Hasania S. , A Study of the Oxidation-induced conformational and functional changes in neuroserpin., Iranian Biomedical J.

19. Mohammadian , Lotfi A. S , Mesbah S.A. , Hasannia S. , Biglarzadeh, Ardalan A., (2006) , Rapid alpha-1-antitrypsin M-variant genotyping by primer-induced Restriction Analysis Diagnostic Molecular pathology. Diagnostic Molecular pathology J.,

20.  Hasannia S. , Lotfi A. S. , Mahboudi F. , Rezai A. , Rahbarizadeh F. and  Mohsenifar A.  ,  (2006) , Elevated Expression of Human Alpha-1 Antitrypsin Mediated by Yeast Intron in Pichia pastoris. Biotechnology Letter J. , 28: 1545-1550

21. Lotfi A. S., Mesbah-Namin S.A , Goudarzi B.G , Zare Mirakabadi A.,(2005), Determination of alpha 1-antitrypsin phenotypes and genotypes in Iranian patients.Iranian Journal of Biotechnology.Volume 3(4): 249-254

22.  Mahdavi Omran S., Lotfi A. S. , Khosravi A., Salehnia M., Zavvaran A.,Chymostatin is a potential inhibitor of induce aspergillosis in murine model.Mycoses J.,(Under revision)

23. Lotfi A. S. , Nejad Ali M. ,Hosseinkhani, Ranjbar B., Mohsenifar A. , Etemadi B. ,(2007), Structural studies of alpha .1.anti trypsin in native and polymer state ,Iranian J. of Biology , 20(1) : 34-42

24. Mahmoodi, Gardiz , Lotfi A. S., Bloom , (2004) , The demonstration of polyethylenimine mediated …,Iranian Biomedical Journal, 8(1):33-39

25. Shams M. , Fazli , Lotfi A. S., Razaghi, (2004), Cellobiose dehydrogennse  production by Genuscladesprim, Iranian Biomedical Journal, 8(2) : 107-111

26. Goodarzi B.G.,  Lotfi A. S. , Zare Mirakabadi A., Mesbah S.A., Bagherian R. , (2004), Isoelectric focusing and PCR-RFLP joined techniques for AAT diticiency detection, Razi Archive, 11(48) : 25-32

27. Mohsenifar A., Lotfi A. S., Ranjbar B., Allameh B., Etemadi B., Hassannia S. , Hasani L., (2005), Oxidation of neuro serpin. a comformatianal disorder, Proceeding of biotech and health congress(Armenia) : 5-10

28. Fazlollahi , Aghamohammadi , Faridhosseini , Lotfi A. S.,  Farhoodi , Movahedi, Gharagozloo,(2006), Stndy of  ά-Antitrypsin phnotypes frequencies in patients with primary antibody deficiency ,Iranian J. of Allergy , Asthma and Immunology , 5(2) : 69-74

29. Moosavi , Yazdan parast, Lotfi A. S. ,(2006), Gtp induces S-phase Cell-cycle Arrest  and Inhibits DNA Synthesis in K562 Cells But Normal Human Peripheral Lymphocytes, Biochemistry Molecular biology , 39 (5) : 492-501

30. Yazdan parast , Moosavi , Mahdavi , Lotfi A. S.,  ,(2006), Guanosine 5' ́-triphosphate induces differentiation-dependent apoptosis in human leukemia U937 and KG1 cells , Acta Pharmacology Sinica, 27(9): 1175-1184

31. Falamaki , Ghodraty, Lotfi A. S., (2006),  A novel method for the synthesis of nanomagnetite. The use of CMC as structure directing agant , Proceeding of the international ,

32. Riazipoor M. , Khosravi, Moosavi , Lotfi A. S., (2005) , Estrase activity and some of its properties in candida Albicance , Kowsar Medical J. , 10(3) :191-200

33. Omidi nia E. , Shahbaz mohammadi H. , Lotfi A. S., Saghiri R., (2007) , Preliminary Report of NAD- dependent amino asid dehydrogenase producing …, Iranian Biomedical J. , (accepted)

34. Mahmoodi M , Islami MR, Asadi Karam GR, Khaksari M, Lotfi A. S., Hajizade MR , Mirzai MR , (2006) , Study of the effects of raw garlic consumption on the level of lipids and other blood biochemical factors in hyperlipidemic individuals , Pak. J. Pharm. Sci. , 19(4): 295-298

35. A.Noghabi K., S.Zahiri H., Lotfi A. S., Rasheb J., Nasri S., C.Yoon S.,(2007),  Mercury absorption by pseudomonas  fluorescens BM07 grown at two different temperatures , Polish J. of Microbiology,  56(2): 111-117

 VII. PAPERS PRESENTED IN REGIONAL AND INTERNATIONAL CONGRESSES :

1. 1st International congress of Islamic Medical Association of North, America, Texas. 1987

2. Lotfi A. S., 8th International congress in clinical enzymology, Sep. 11- 14 1998, Osaka, Japan

3. Lotfi A. S., Javadi, 3rd International congress in Geographic Medicine Oct. 30- Now3, Shiraz, Iran.

4. 14th Annual conference association of Clinical biochemists of India, Feb. 27-29. 1988, Udaipur. India.

5. 2nd International congress in protein structure and function relationship Dec. 11- 14. 1989. Karachi. Pakistan.

6. 8th European congress of clinical chemistry. June. 25- 30. 1989. Milan. Italy.

7. 1st International congress in application of HPLC in enzyme chemistry, Sep. 14- 17, 1990, Verona, Italy

8. 5th Asian - pacific congress of clinical biochemistry Sep 29. Oct. 4. 1991, Kobe, Japan.

9. 1st International conference of pharmaceutical sciences, Jan. 18- 21 1991, Karachi, Pakistan.

10.  3rd International Symposium on protein structure function relation ship and workshop, Jan. 9-33. 1993, Karachi, Pakistan.

11. 2nd International congress on application of HPLC and CE in the biosciences, Sep. 7-10, 1993, Verona, Italy.

12. 15th International congress of clinical chemistry, Nov. 14-19, 1993, Melbourne, Australia. 

13.  1st Afero - Arab congress of clinical laboratory, Apr. 25- 28, 1994, Damascus, Syria.

14. 16th International congress of biochemistry and molecular biology, Sep. 19- 22, 1994, New Delhi, India.

15. 16th International congress of clinical chemistry, Ju1.12, 1996, London, UK.

16. 2nd Workshop on isolation purification and sequencing of proteins, Dec. 1-10, 1989, Karachi, Pakistan.

17. 1st workshop on Immunochemical techniques, 12- 28 Nov. 1991, Karachi, Pakistan.

18. 8th Asian - Pacific congress of clinical biochemistry, 11-15, Oct. 1998, Kuala Lumpur, Malaysia.

19. 9th Arab clinical biology, 12- 16 May, 2000, Rabat, Morocco.

20. Is there correlation between serum α1-AT levels and myocardial infarction risk factors, International conference, coronary heart disease in the new millennium, 26-28 March 2001, Kuwait.

21. EuroMedLab 2001, 14th IFCC -FESCC European congress of clinical chemistry and laboratory medicine 2001, Prague, Czech.

22. The clinical value of serum lactate dehydrogenase and its isoenzymes in chronic leukemia patients,6th European Hematology congress 21-24 Jun 2001 Frankfurt, Germany.

23. Differential responses of the brain glutathiones- transferase to theophilin in adult and weanling rats, Eurotox 2001, 13-16 Sep. 2001, Istanbul, Turkey.

24. Asian International Mycological congress, 17-20 Sep., 2001, Karaj, Iran.

25. (Evaluation of immunoglobuline A-AAT complex as stage diagnosis marker in sera of patients with rheumatoid arthritis by enzyme linked immnno sorbent assay) 9th Asian Pacific congress of clinical biochemistry ,9-14Mar.2002, New Delhi, India

26. (Evaluation of polyacrylamide gel electrophoresis to differatiate high virulent and low virulent of candida albicans)The 18th International congress of clinical chemistry ,20-25Oct.2002, Kyoto, Japan

 27.  EuroMed Lab., 1-5 June 2003 , Barcelona , Spain

28. The XIV congress of European mycologists , 22-27 Sep. 2003 , karima , Ukraine 

29. (Screening of envrionmental and clinical cladosporium isolates for cellobiose dehydrogenese production)9th APCCB & 28th annual conference of ACBI, 9-14 March 2002,         New Delhi, India

30. The 22nd world congress of  Pathology and Laboratory medicine, Bussan, South Korea

31. 7th Iranian congress of biochemistry, 26-29 Jan. 2004 , Ahvaz ,Iran

32. EuromedLab 2001 , Milan, Italy

33. The 10th Asian Pacific congress of clinical Biochemistry, 18-23 Sep. 2004, Australia, Pert,

34. 10th Asian Pacific  congress of clinical Biochemistry, 18-23 Sep. 2004, Australia, Perth,

35.10th congress of the European confederation of medical mycology, Feb. 2004, Hungary

36. 18th international congress of clinical chemistry and laboratory medicine, 20-25 Oct. 2002 , Japan, Kobe

37. First international congress on Immunodeficiency discords,                  

28 Feb.- 2 March 2005 , Tehran, Iran

38.  30th FEBS congress and 9th IUBMB conference, 2-7 July 2005, Budapest, Hungary

39. 18th internation congress of clinical chemistry and laboratory medicine(Increased excretion of fatty acid metabolites in urine of patvents with mediunchain acylcoa dehydrogenase deficiency as an indicator in diagnosis of the disease)

40. (chymostatin and inhibition of Aspergillons)10th Congress of the European Confederation of medical my cology 

41. (The role of  polymerized AAT in bile of gallbladder chelesterol crystaliention) 10th Asian Pacific Congress of Clinical Biochemistr 

42. (Diagrosis of AAT deficiency by ITC, IEF and PCR-RFLP)10th Asian Pacific congress of Clinical Biochemistry 

43. (AAT polymerization and its effects on cholestrol crystalization in callstone disease The 22nd world congress of  pathology and laboratory medicine

44. (  Detection of matrix melallo proteinase (MMPS) 2qqin the human proovulatory to llicular fluid) 2003 10th Arian-pacific congress of clinical biochemists

45. (Cellobiose dehydrogenase production by the Genns cladesprrium) 2003.XIU congress of fnropean  Mycologists

46. (Alpha-1-Mtidrypsin polymerization in cholestrol Gallstone Pathogenesis) 2003Euromed Lab Barcelona

47. (Bath and Continuons production of L- lactic acid from whey using free and immobilized culture of lactobacilli) 2003 First national Biotechnology Congress

48. (Evaluation of immunoglobuline A-a1AT complex as a stage drugnostic marker in sera of patients with rheumatoid arthritis by ELISA) 1991 The 18th International Congress of Clinical Chemistry and Laboratory Medicine

49. (Differential responses of the brain glutathione-s-transferase to the ophilin in adult and weanling rats)Eurotox 2001

50. (Evaluation of polyacrylamide gel electrophoresis to defferentiate high virulent and low virula to stains of candida albicans) 2002The 18th International Congress of Clinical Chemistry and Laboratory  Medicine

51. (Sovecning of environmental and clinical clados porium isolates for cellobiose dehydrogenase production)The 18th International Congress of clinical chemistary

52. ( Detection of     matrix metallo proteinase 2&9 in the human preovulatory follicular fluid) 4th Asian Pacific Cngress of Clinical Biochemistry (APCCB)-

53. (Asporgillus niger is a rich source for production of glucose oxidase)2001 Asian International mycological congress 2001

54. (Intracellular estrase activity in candida albicans and its evaluation as a virulen marker)Asian International  mycological congress 2001

54. (The clinical value of serum Lactate   detlydrogenase and its isoenzynes in chronic leukemia patients)6th European Hematology Congress.

55. (Identification of matrix metattoproteinases 2&9   in the human preovulatory follicular fluid)Euro Medlab 2001, 14th IFCC-FESCC European Congress of clinical   chemistry and Laboratory Medicine

56. (Is there  correlation between serum a1-AT levels and myocardial infarction risk factors)2001 International conference coronary heart disease in the new millennium

57. (AAT polymerization and its effectson cholestrol crystalization in callstone disease)The 22nd world congress of pathology and laboratory medicine

58 . (study effect of Toxin on G-6-DD level in blood)7th International congress of enzymyology (Japan)

59. (Study of bioprotein on athletes with spinal disorders) 8th European congress of Clinical chemistry. Milan Italy

60. (Purification of some proteins from antigen of different Species)2nd International Congress of Function & Structure of Proteins. Karachi. Pakistan.

61. (Measurement of Urine lysosome for early diagnosis of kidney disorders)1st International Congress of HPLC utility on enzyme chemistry. Verdna. Italy

62. (Study on NAG enzyme on esophagus cancer) 5th Asia clinical biochemistry Kuwait

63. (study of betagalactosids on urine of  chronic kidney disorder) 1st International congress of medicine science .Karachi .Pakistan

64. (Plasma analysis of patient with esophagus cancer with 2d electrophoriz 15th International congress of  Clinical biochemistry .Melborn Australia

65. (detective of one protein tumor in esophagus cancer)3rd International congress of Structural and function of proteins .Karachi .Pakistan

64. (HPLC utility on plasma protein and cancer tissue )2nd International symposium of HPLC utility & CE on biology Science . verena Italy.

65. (Study of some chemical sign of asthma )1st west African congress of medical Laboratory .damask .saurian

66. (Lactat dehudrogenaz enzyme on leukemia.)16th International congress of biochemistry and molecular biology. new Delhi

67. study of esophagus progress with some key enzyme in glycolic path on esophagus mucosal tissue .16th International congress of Clinical chemistry .London .England

68. )Identification of matrix metalloproteiases II   and VIII  in the human preovulatory follicalar fluid)Euromed Lab 2001